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If you want to disable any context menu item in devexpress grid like this. In XAML <dxg:GridControl x:Name="grdProfile" Width="1070" Height="400" HorizontalAlignment="Left" VerticalAlignment="Top" AutoGenerateColumns="None" ItemsSource="{Binding CusHisViewRefillHistoryList}" SelectedItem="{Binding SelectedCusHisViewRefillHistory}"> <dxg:GridControl.Columns> <dxg:GridColumn Width="100" Binding="{Binding RxNo}" Header="Rx #" /> <dxg:GridColumn Width="70" Binding="{Binding PhInitials}" Header="Ph. Initials" /> ...